Midazolam inhibits IgE production in mice via suppression of class switch recombination

Molecular Mechanisms of IgE Class Switch Recombination.

Immunoglobulin (Ig) E is the most tightly regulated of all Ig heavy chain (IgH) isotypes and plays a key role in atopic disease. The gene encoding for IgH in mature B cells consists of a variable region exon-assembled from component gene segments via V(D)J recombination during early B cell development-upstream of a set of IgH constant region CH exons. Upon activation by antigen in peripheral ly...

IgE class switch recombination is regulated by CaMKII via NF-κB alternative pathway

IgE class switch recombination (CSR) is under the tight control to maintain the low concentration of serum IgE. IL-4 and CD40 signal induces IgE CSR. NF-κB classical pathway and STAT6 was indicated in this pathway. In this study, we prepared a M12 cell line expressing TRAF3 in an inducible manner. This cell line showed impaired signal transduction of NF-κB alternative pathway and diminished exp...

onychomadesis in a patient with immunoglobulin class switch recombination deficiency

immunoglobulin class switch recombination deficiencies (ig csr deficiencies) or hyper igm syndromes (higm) are a group of primary immunodeficiency diseases, characterized by defective cd40 signaling of b cells resulting into a csr and a somatic hypermutation. the affected patients are characterized with reduced serum levels of igg and iga, and normal or elevated level of igm, which lead to incr...

Immunoglobulin Class Switch Recombination Is Impaired in Atm-deficient Mice

Immunoglobulin class switch recombination (Ig CSR) involves DNA double strand breaks (DSBs) at recombining switch regions and repair of these breaks by nonhomologous end-joining. Because the protein kinase ataxia telengiectasia (AT) mutated (ATM) plays a critical role in DSB repair and AT patients show abnormalities of Ig isotype expression, we assessed the role of ATM in CSR by examining ATM-d...

Interallelic Class Switch Recombination